Hippocampal dynamics predict interindividual cognitive differences in rats.
Take-home message: Individual memory in old rats was assessed using DNMS. We recorded hippocampal CA1 place cells as these rats exploreda familiar environment; 27% of recorded pyramidal neurons showed substantial delayed onsets of place field activity. This age-related firing onset delay occurred under basal conditions; it was strongly and positively correlated with place field instability in memory-impaired animals. In other words, individual differences matter, and matter a lot, especially when examining the dynamics of ageing. [Download the paper here.]
J Neurosci. 2012 Mar 7;32(10):3540-51. doi: 10.1523/JNEUROSCI.6449-11.2012.
There are important and sustained interindividual differences in cognition during aging. Here, we investigated hippocampal spatial representations in a rat…
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