Synaptic plasticity in the subiculum (our first papers on subiculum, from a long time ago)

Take-home messages: The projection from hippocampal area CA1 to the subiculum sustains long-term potentiation in vivo [download the paper], and LTP reduces paired-pulse facilitation in this pathway [download the paper]. The subiculum continues to be underexplored relative to the rest of the hippocampal formation, despite its interesting connections with the anterior thalamus, among regions. Neuroreport. 1998 Mar 30;9(5):847-50. The… Read More

Analysis of recordings of single-unit firing and population activity in the dorsal subiculum of unrestrained, freely moving rats.

Analysis of recordings of single-unit firing and population activity in the dorsal subiculum of unrestrained, freely moving rats. Take-home message: our first attempt at classifying the electrophysiological phenotypes of subicular neurons recorded in vivo. We suggest that subicular neurons can be classified into four types: bursting units, regular spiking units, theta-modulated units, and fast spiking units. We… Read More

Hierarchy works

Originally posted on Flip Chart Fairy Tales:
There has been a lot of excitement about Zappos new hierarchy free, self-organising, boss-less organisation. The holocracy, as it’s known, is all very zeitgeisty. My Twitter timeline is full of articles about smashing corporate hierarchies and getting rid of executives. Last year, Gary Hamel, described in Fortune magazine as ‘the world’s…

Differential regulation of synaptic plasticity of the hippocampal and the hypothalamic inputs to the anterior thalamus.

Differential regulation of synaptic plasticity of the hippocampal and the hypothalamic inputs to the anterior thalamus. Take-home message: different forms of long-term synaptic plasticity are expressed in the direct and indirect pathways from the hippocampal formation converging on the anterior thalamic nuclei. [Download the paper] Hippocampus. 2011 Jan;21(1):1-8. doi: 10.1002/hipo.20749. Tsanov M, Vann SD, Erichsen… Read More

Selective disconnection of the hippocampal formation projections to the mammillary bodies produces only mild deficits on spatial memory tasks: implications for fornix function.

Selective disconnection of the hippocampal formation projections to the mammillary bodies produces only mild deficits on spatial memory tasks: implications for fornix function. Take-home message: the mammillary bodies can  support spatial memory without their dense subicular complex inputs, revealing the importance of the other afferents for sustaining mammillary body function. This new evidence for independent functions… Read More

Here’s why the MOOCs don’t work… (and maybe how they can be made to work)

I spent some time over the holidays looking at some MOOC offerings – either the freebie intro lectures available from some of the major providers, or the clips available on YouTube. I also had a look at some course content, syllabi and related materials. This trawl is, of course, not representative or even properly systematic… Read More

Managing your brain to optimise learning and memory: Some notes

This is a short popular media piece I wrote a while back for the Memory Lab exhibition (2011) on managing your brain to optimise learning and memory. I dug it out after receiving a few emails on this topic regarding study advice. There are two general things you can do – manage your lifestyle, and manage… Read More