The irregular firing properties of thalamic head direction cells mediate turn-specific modulation of the directional tuning curve

Take-home message: Anterior thalamic head direction cells are interesting in all sorts of ways. Here, we show that head direction cells remain active during sleep (how interesting is that?!), replicate the finding that these cells fire at different rates depending on whether the head makes clockwise or counterclockwise movements, and that the origin of this difference might lie in the intrinsic firing properties of these neurons. [Download the paper]

The irregular firing properties of thalamic head direction cells mediate turn-specific modulation of the directional tuning curve

Marian Tsanov , Ehsan Chah , Muhammad S. Noor , Catriona Egan , Richard B. Reilly , John P. Aggleton , Jonathan T. Erichsen , Seralynne D. Vann , Shane M. O’Mara
Journal of Neurophysiology

Published 13 August 2014

Equivalent circuit for the cell membrane in th...
Equivalent circuit for the cell membrane in the Hodgkin-Huxley model (Photo credit: Wikipedia)

Vol. no. DOI: 10.1152/jn.00583.2013

ABSTRACT

Head-direction cells encode an animal’s heading in the horizontal plane. However, it is not clear why the directionality of a cell’s mean firing rate differs for clockwise, compared to counter-clockwise head turns (this difference is known as the ‘separation angle’) in anterior thalamus. Here we investigated, in freely-behaving rats, if intrinsic neuronal firing properties are linked to this phenomenon. We found a positive correlation between the separation angle and the spiking variability of thalamic head-direction cells. To test whether this link is driven by hyperpolarisation-inducing currents, we investigated the effect of thalamic reticular inhibition during high-voltage spindles on directional spiking. While the selective directional firing of thalamic neurons was preserved, we found no evidence for entrainment of thalamic head-direction cells by high-voltage spindle oscillations. We then examined the role of depolarisation-inducing currents in the formation of separation angle. Using a single-compartment Hodgkin-Huxley model, we show that modelled neurons fire with higher frequencies during the ascending phase of sinusoidal current injection (mimicking the head-direction tuning curve), when simulated with higher high-threshold calcium channel conductance. These findings demonstrate that the turn-specific encoding of directional signal strongly depends on the ability of thalamic neurons to fire irregularly in response to sinusoidal excitatory activation. Another crucial factor for inducing phase lead to sinusoidal current injection was the presence of spike-frequency adaptation current in the modelled neurons. Our data support a model in which intrinsic biophysical properties of thalamic neurons mediate the physiological encoding of directional information.

Author: Shane O'Mara

Neuroscientist

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