Remind me again why aerobic exercise is good for my brain (and mood, and thinking)…

There are lots of reasons why regular aerobic exercise is good for the brain – the effects of exercise on brain volume, cognition and mood are profound and enduring. Here are a few key papers. In an early review paper, Colcombe and Kramer (2003) conducted a meta-analysis of 18 interventional studies, conducted over a 25-year period. Their… Read More

Resveratrol as an exercise mimetic – direct comparisons with aerobic exercise, and positive effects on cognitive function: Our posters from Society for Neuroscience ’11, ’12, ’13

Aerobic exercise has marked effects on cognitive function, even in an elderly group at risk for  Alzheimer’s disease. Aerobic exercise may not be suitable for certain groups, especially the frail or those at risk of falls. Exercise mimetics may therefore prove an attractive for treatment option the frail, who would benefit from exercise-induced changes in peripheral and central function. The polyphenol, resveratrol, rose to… Read More

Physical Activity and the Prevention of Depression: A Systematic Review of Prospective Studies

Important systematic review evidence for the efficacy of physical activity on mood, adding further to the evidence base that exercise plays a very positive neuroregulatory role (see also this Cochrane systematic review downloadable here; and some of our own work here). Am J Prev Med. 2013 Nov;45(5):649-57. doi: 10.1016/j.amepre.2013.08.001. Physical activity and the prevention of depression: a systematic… Read More

Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males.

Take-home message: It is becoming increasingly accepted that substantial, sustained low-impact aerobic exercise has profound effects on neurocognitive function in the aged (see, for example, this very important paper from Art Kramer’s group). We here focus on a young and sedentary population, using tasks that tap into hippocampal function. We also measure circulating brain-derived neurotrophic factor (BDNF) as a proxy for brain BDNF. We… Read More

Evidence for cognitive-enhancing effects of modafinil and methylphenidate is surprisingly thin – perhaps because wakefulness-promotion and cognitive enhancement are confused

There is huge media and other interest in cognitive-enhancing drugs. A few minutes searching on the internet will uncover stories of students and others using modafinil and some other compounds in an effort to enhance their own cognitive function. The evidence for the cognitive-enhancing effects of these compounds is surprisingly thin, however, despite claims about… Read More