Resveratrol as an exercise mimetic – direct comparisons with aerobic exercise, and positive effects on cognitive function: Our posters from Society for Neuroscience ’11, ’12, ’13

Aerobic exercise has marked effects on cognitive function, even in an elderly group at risk for  Alzheimer’s disease. Aerobic exercise may not be suitable for certain groups, especially the frail or those at risk of falls. Exercise mimetics may therefore prove an attractive for treatment option the frail, who would benefit from exercise-induced changes in peripheral and central function. The polyphenol, resveratrol, rose to… Read More

How many drug trials for Alzheimer’s disease have failed? Why do so many new therapeutic drugs fail in development?

This topic came up in the context of a conversation with my colleagues in the Science Gallery, who are putting on an exhibition called Fail, which will explore the question: ‘Can we change our perception of failure in order to embrace this essential driver of innovation?’ There have been many failed Alzheimer’s disease drug trials. This is… Read More

Impaired capacity for autonoetic reliving during autobiographical event recall in mild Alzheimer’s disease

Take-home message: Autonoesis or ‘Autonoetic consciousness is the human ability to mentally place ourselves in the past, in the future, or in counterfactual situations, and to analyze our own thoughts‘ (wiki). Here, we focus on impairments of autonoesis in Alzheimer’s disease (AD), using the Episodic Autobiographical Memory Interview (EAMI). We find impairments in AD patients with the following pattern: AD [Download the paper]… Read More

Exploring the recollective experience during autobiographical memory retrieval in amnestic mild cognitive impairment.

Take-home message: there are greater levels of autobiographical memory (memory for the episodes and events of your life and general knowledge of the world) impairment in amnestic mild cognitive impairment (aMCI: a greater than expected deficit in cognitive function for age and education) seen than previously assumed. More on MCI, which is often thought of as being prodromal for Alzheimer’s disease (AD), as a proportion of… Read More