Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457.

Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457 (available here) Callaghan CK, Hok V, Della-Chiesa A, Virley DJ, Upton N, O’Mara SM. Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland. callaghc@tcd.ie Abstract Alterations in synaptic plasticity and neurocognitive function with age have been well documented in the literature. These changes are… Read More

CREB selectively controls learning-induced structural remodeling of neurons.

Learn Mem. 2012 Jul 18;19(8):330-6. doi: 10.1101/lm.025817.112. CREB selectively controls learning-induced structural remodeling of neurons. [download] Middei S, Spalloni A, Longone P, Pittenger C, O’Mara SM, Marie H, Ammassari-Teule M. Source CNR-National Research Council, Rome 00143, Italy. s.middei@hsantalucia.it Abstract The modulation of synaptic strength associated with learning is post-synaptically regulated by changes in density and shape of dendritic spines. The transcription factor… Read More