First-in-class thyrotropin-releasing hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models

First-in-class thyrotropin-releasing hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models Highlights First-in-class TRH-based compound JAK4D detects new receptor subtype in human brain. JAK4D elicits statistically significant effects in neurodegenerative animal models. JAK4D crosses the blood–brain barrier and has a clean initial toxicology profile.… Read More

Rosiglitazone enhances learning, place cell activity, and synaptic plasticity in middle-aged rats.

Rosiglitazone enhances learning, place cell activity, and synaptic plasticity in middle-aged rats. Wang BW, Hok V, Della-Chiesa A, Callaghan C, Barlow S, Tsanov M, Bechara R, Irving E, Virley DJ, Upton N, O’Mara SM. [Download here] Neurobiol Aging. 2012 Apr;33(4):835.e13-30. doi: 10.1016/j.neurobiolaging.2011.08.013. Epub 2011 Oct 4. Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland. Abstract As an antidiabetic agent, rosiglitazone (ROSI) binds and activates peroxisome proliferator-activator… Read More

Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457.

Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457 (available here) Callaghan CK, Hok V, Della-Chiesa A, Virley DJ, Upton N, O’Mara SM. Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland. callaghc@tcd.ie Abstract Alterations in synaptic plasticity and neurocognitive function with age have been well documented in the literature. These changes are… Read More