Long-term cognitive dysfunction in the rat following docetaxel treatment is ameliorated by the phosphodiesterase-4 inhibitor, rolipram.

Long-term cognitive dysfunction in the rat following docetaxel treatment is ameliorated by the phosphodiesterase-4 inhibitor, rolipram. Our latest paper [download] focuses on chemobrain – the mental fog or fuzziness that can accompany and follow chemotherapy. Behav Brain Res. 2015 May 1;290:84-89. doi: 10.1016/j.bbr.2015.04.044. [Epub ahead of print] Callaghan CK, O’Mara SM. Clinical studies report evidence of long-term… Read More

The Connected Hippocampus, 1st Edition | Shane O’Mara, Marian Tsanov | ISBN 9780444635495

The Connected Hippocampus, 1st Edition | Shane O’Mara, Marian Tsanov | ISBN 9780444635495 The purpose of this volume is to encourage researchers to situate the hippocampus as part of a network connected to the rest of the brain and not to consider it in isolation. We therefore present a selection of chapters that concentrate on… Read More

Cover Art for my new book with HUP – Why Torture Doesn’t Work: The Neuroscience of Interrogation

I have a new book due to appear (Autumn/Fall 2015) with Harvard University Press. Update: now available for preorder via Amazon (.com) Amazon (.co.uk) Harvard University Press Here’s the cover art (which is copyrighted HUP, so usual warnings apply regarding reproduction): Why Torture Doesn’t Work: The Neuroscience of Interrogation Shane O’Mara Torture is banned because it is cruel and inhumane. But… Read More

Decoding signal processing in thalamo-hippocampal circuitry: implications for theories of memory and spatial processing.

Our latest paper, focusing on signals afferent to the hippocampal formation as determinants of hippocampal dynamics, and therefore memory and spatial cognition [download]. Brain Res. 2014 Dec 9. pii: S0006-8993(14)01672-2. doi:10.1016/j.brainres.2014.12.003. Decoding signal processing in thalamo-hippocampal circuitry: implications for theories of memory and spatial processing. Tsanov M, O׳Mara SM Highlights Thalamo-hippocampal projections are vital for episodic… Read More

Fornical and non-fornical projections from the rat hippocampal formation to the anterior thalamic nuclei.

Our latest paper available for download. We find that contrary to previous descriptions, projections from the subiculum to the anteromedial thalamic nucleus overwhelmingly relied on the fornix, whereas postsubicular inputs to the lateral dorsal part of the anteroventral nucleus, as well as to the anterodorsal and laterodorsal thalamic nuclei, largely proceed via the internal capsule (a non-fornical… Read More

Decoding signal processing in thalamo-hippocampal circuitry: implications for theories of memory and spatial processing

Decoding signal processing in thalamo-hippocampal circuitry: implications for theories of memory and spatial processing Marian Tsanov and Shane M. O’Mara Our latest paper. Highlights • Thalamo-hippocampal projections are vital for episodic memory formation. • There is extensive connectivity between these structures. • We examine the signals processed within this circuitry. • We focus on head… Read More

#sfn14 – As time goes by: The gradual impact of chronic stress on rodent hippocampal structure and function

I won’t be there but go see our poster anyway – presented by Mostafizur Rahmen. Program#/Poster#: 745.05/SS30 Presentation Title: As time goes by: The gradual impact of chronic stress on rodent hippocampal structure and function Location: WCC Hall A-C Presentation time: Wednesday, Nov 19, 2014, 8:00 AM -12:00 PM Presenter at Poster: Wed, Nov. 19,… Read More

John O’Keefe being interviewed after his Nobel Prize win

John O’Keefe published his astounding paper (The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat) on the discovery of hippocampal place cells in 1971, using behavioural neurophysiological techniques that were difficult to establish and rare in nature. Place cells changed forever what we thought of the hippocampus and temporal lobe, and a vast… Read More

Cognition enhancement via drugs – “Smart and smarter drugs | Mosaic”

Embed from Getty Images Great piece on a topic we have dealt with here before – allegedly cognition-enhancing drugs. via Smart and smarter drugs | Mosaic. Author: Marek Kohn Editor: Giles Newton Copyeditor: Kirsty Strawbridge Fact checker: Lowri Daniels Illustrator: Mari Kanstad Johnsen Art director: Peta Bell “You know how they say that we can only access 20 per cent of our… Read More

The subiculum: what it does, what it might do, and what neuroanatomy has yet to tell us.

Take-home message: a combined review and theory, presenting some ideas on the functions of the subiculum. I argue that there is a dorso-ventral segregation of function within the subiculum: the dorsal component appears principally concerned with the processing of information about space, movement and memory, whereas the ventral component appears to play a major regulatory role… Read More