Hippocampal dynamics predict interindividual cognitive differences in rats.

Hippocampal dynamics predict interindividual cognitive differences in rats. Take-home message: Individual memory in old rats was assessed using DNMS. We recorded hippocampal CA1 place cells as these rats explored a familiar environment; 27% of recorded pyramidal neurons showed substantial delayed onsets of place field activity. This age-related firing onset delay occurred under basal conditions; it was… Read More

Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457.

Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457 (available here) Callaghan CK, Hok V, Della-Chiesa A, Virley DJ, Upton N, O’Mara SM. Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland. callaghc@tcd.ie Abstract Alterations in synaptic plasticity and neurocognitive function with age have been well documented in the literature. These changes are… Read More

Hangover nation: What is it about Ireland and drink?

A piece I did for the Irish Examiner a little while back: We drink too much in Ireland. As a nation, we consistently place highly in the global heavy drinking league. Excess alcohol consumption causes many problems. It is, for example, the major cause of death in men aged 35 to 50 in Ireland. A HSE report… Read More

Terrorism, Torture and Memory: Royal Irish Academy | About | Science Series

[My book ‘Why Torture Doesn’t Work: The Neuroscience of Interrogation’ (Harvard UP) can be preordered from Amazon (.com) – more details at end of post] Royal Irish Academy | About | Science Series via Royal Irish Academy | About | Science Series. This links to a podcast of an unusual interdisciplinary evening, featuring a neuroscientist (me), a political scientist (Richard… Read More

The anterior thalamus provides a subcortical circuit supporting memory and spatial navigation.

The anterior thalamus provides a subcortical circuit supporting memory and spatial navigation. Front Syst Neurosci. 2013 Aug 30;7:45. Jankowski MM, Ronnqvist KC, Tsanov M, Vann SD, Wright NF, Erichsen JT, Aggleton JP, O’Mara SM. Trinity College Institute of Neuroscience, Trinity College Dublin Dublin 2, Ireland. Abstract The anterior thalamic nuclei (ATN), a central component of Papez‘ circuit, are generally assumed to be key… Read More