The stressed brain… Impacts on work, business and cognition

Popular media suggest that modern society is afflicted by stress: Google yields 154,000,000 hits for ‘stress’  and 36,700,000 hits for ‘stress epidemic’. Current EU estimates suggest work-related stress (defined as “a pattern of emotional, cognitive, behavioural and physiological reactions to adverse and noxious aspects of work content, work organisation and work environment. Stress is caused by… Read More

Roles for the cyclooxygenases (especially COX 2) in learning and memory, as well as in synaptic plasticity.

A pair of papers which focus on the role the inducible inflammatory regulating enzyme COX2 plays in learning and memory. These papers proceeded from earlier work of ours, showing that the bacterial endotoxin lipopolysaccharide (LPS) blocked synaptic plasticity but not synaptic transmission CA1-subiculum pathway in vivo. LPS induces the expression of COX2, amongst other things, and it seemed reasonable to… Read More

CREB selectively controls learning-induced structural remodeling of neurons.

Learn Mem. 2012 Jul 18;19(8):330-6. doi: 10.1101/lm.025817.112. CREB selectively controls learning-induced structural remodeling of neurons. [download] Middei S, Spalloni A, Longone P, Pittenger C, O’Mara SM, Marie H, Ammassari-Teule M. Source CNR-National Research Council, Rome 00143, Italy. s.middei@hsantalucia.it Abstract The modulation of synaptic strength associated with learning is post-synaptically regulated by changes in density and shape of dendritic spines. The transcription factor… Read More

Interactions Between Paired-Pulse Facilitation, Low-Frequency Stimulation And Behavioral Stress In The Pathway From Hippocampal Area CA1 To The Subiculum: Dissociation Of Baseline Synaptic Transmission From Paired-Pulse Facilitation And Depression Of The Same Pathway.

Here’s an old and difficult to access paper (Download: Commins & O’Mara Psychobiol) of ours from Psychobiology – from the days before all journals were online. Hard to remember those days now… Psychobiology evolved into Cognitive, Affective, & Behavioral Neuroscience (see past titles here – scroll to bottom). (This is the longest title on any paper I have ever published…) Commins,… Read More