The stressed brain… Impacts on work, business and cognition

Popular media suggest that modern society is afflicted by stress: Google yields 154,000,000 hits for ‘stress’  and 36,700,000 hits for ‘stress epidemic’. Current EU estimates suggest work-related stress (defined as “a pattern of emotional, cognitive, behavioural and physiological reactions to adverse and noxious aspects of work content, work organisation and work environment. Stress is caused by… Read More

Roles for the cyclooxygenases (especially COX 2) in learning and memory, as well as in synaptic plasticity.

A pair of papers which focus on the role the inducible inflammatory regulating enzyme COX2 plays in learning and memory. These papers proceeded from earlier work of ours, showing that the bacterial endotoxin lipopolysaccharide (LPS) blocked synaptic plasticity but not synaptic transmission CA1-subiculum pathway in vivo. LPS induces the expression of COX2, amongst other things, and it seemed reasonable to… Read More

Roles for the subiculum in spatial information processing, memory, motivation and the temporal control of behaviour.

Take-home message: The subiculum is in a pivotal position governing the output of the hippocampal formation. Despite this, it is a rather under-explored and sometimes ignored structure. Here, we discuss recent data indicating that the subiculum participates in a wide range of neurocognitive functions and processes. More research required! [Download the paper] Roles for the subiculum… Read More