Decoding signal processing in thalamo-hippocampal circuitry: implications for theories of memory and spatial processing

Decoding signal processing in thalamo-hippocampal circuitry: implications for theories of memory and spatial processing Marian Tsanov and Shane M. O’Mara Our latest paper. Highlights • Thalamo-hippocampal projections are vital for episodic memory formation. • There is extensive connectivity between these structures. • We examine the signals processed within this circuitry. • We focus on head… Read More

The persisting effects of electroconvulsive stimulation on the hippocampal proteome.

Our latest paper; download here. The persisting effects of electroconvulsive stimulation on the hippocampal proteome. Brain Res. 2014 Dec 17;1593C:106-116. doi: 10.1016/j.brainres.2014.10.020. Epub 2014 Oct 22. O’Donovan SM, O’Mara SM, Dunn MJ, McLoughlin DM. Electroconvulsive therapy (ECT) is the most acutely effective treatment available for severe depression. However, its mechanism of action is not fully understood. Elucidating… Read More

John Waters (not the other one) on depression: ‘Not even wrong’

John Waters (the columnist, not the other one – don’t confuse them!) is quoted in today’s Sunday Independent as follows: “I don’t believe in depression. There’s no such thing. It’s an invention. It’s bullshit,” he said, “it’s a cop out.” To which I can only say ‘wow’! There are at least two possibilities here. The first is that he… Read More

Validation of the face-name pairs task in major depression: impaired recall but not recognition

Take-home Message: memory – and especially associative memory – is impaired in a wide variety of neuropsychiatric and neurological conditions. Face-name pair learning is a useful method to tap into deficits in associative memory; usefully, it is a task dramatically impaired by lesions of the extended hippocampal formation. Here, we show that patients with depression showed… Read More

Risk factors for the development of depression in patients with hepatitis C taking interferon-α

Risk factors for the development of depression in patients with hepatitis C taking interferon-α Neuropsychiatr Dis Treat. 2011;7:275-92. doi: 10.2147/NDT.S13917. Epub 2011 May 15. [Download the paper] Smith KJ, Norris S, O’Farrelly C, O’Mara SM. Trinity College Institute of Neuroscience. Interferon-α, currently used for the treatment of hepatitis C, is associated with a substantially elevated risk of depression. However,… Read More

Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457.

Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457 (available here) Callaghan CK, Hok V, Della-Chiesa A, Virley DJ, Upton N, O’Mara SM. Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland. callaghc@tcd.ie Abstract Alterations in synaptic plasticity and neurocognitive function with age have been well documented in the literature. These changes are… Read More