Selective disconnection of the hippocampal formation projections to the mammillary bodies produces only mild deficits on spatial memory tasks: implications for fornix function.

Selective disconnection of the hippocampal formation projections to the mammillary bodies produces only mild deficits on spatial memory tasks: implications for fornix function. Take-home message: the mammillary bodies can  support spatial memory without their dense subicular complex inputs, revealing the importance of the other afferents for sustaining mammillary body function. This new evidence for independent functions… Read More

Exercise, but not environmental enrichment, improves learning after kainic acid-induced hippocampal neurodegeneration in association with an increase in brain-derived neurotrophic factor.

Take-home message: further evidence that aerobic exercise provides substantial neuroprotection against brain insult, even if there are equivalent losses of neurons in key brain regions compared to sedentary controls. [Download the paper] Much more on exercise. Exercise, but not environmental enrichment, improves learning after kainic acid-induced hippocampal neurodegeneration in association with an increase in brain-derived neurotrophic… Read More

Stability of subicular place fields across multiple light and dark transitions.

Stability of subicular place fields across multiple light and dark transitions. Take-home message: subicular place cells have larger and coarser place cells than CA1 cells; a plurality of subicular cells are stable across multiple light-dark-light transitions, however (not too dissimilar to CA1 cells).  [Download the paper.] Eur J Neurosci. 2010 Aug;32(4):648-58. doi: 10.1111/j.1460-9568.2010.07308.x. Brotons-Mas JR,… Read More

Physical Activity and the Prevention of Depression: A Systematic Review of Prospective Studies

Important systematic review evidence for the efficacy of physical activity on mood, adding further to the evidence base that exercise plays a very positive neuroregulatory role (see also this Cochrane systematic review downloadable here; and some of our own work here). Am J Prev Med. 2013 Nov;45(5):649-57. doi: 10.1016/j.amepre.2013.08.001. Physical activity and the prevention of depression: a systematic… Read More

Hippocampal-anterior thalamic pathways for memory: uncovering a network of direct and indirect actions.

Our major theoretical take and review of the extended brain systems that support explicit, declarative memory in the brain. [Download the paper.] Take-home message: there’s a lot more to memory than the hippocampal formation, and you forget (!) the connected thalamic structures at your peril, because the anterior thalamus provides a subcortical circuit supporting memory and spatial… Read More

Are People Overoptimistic about the Effects of Heavy Drinking? [J Risk Uncertain. 2013] – PubMed

Heavy drinkers have a sense that excessive alcohol consumption isn’t doing them much good. But, paradoxically, they believe the rapid and complex visuomotor integration required for driving is unaffected. Presumably the lack of conscious access to the non-declarative habit systems of the brain (tell me exactly how to drive a car, play a musical instrument… Read More

Rosiglitazone enhances learning, place cell activity, and synaptic plasticity in middle-aged rats.

Rosiglitazone enhances learning, place cell activity, and synaptic plasticity in middle-aged rats. Wang BW, Hok V, Della-Chiesa A, Callaghan C, Barlow S, Tsanov M, Bechara R, Irving E, Virley DJ, Upton N, O’Mara SM. [Download here] Neurobiol Aging. 2012 Apr;33(4):835.e13-30. doi: 10.1016/j.neurobiolaging.2011.08.013. Epub 2011 Oct 4. Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland. Abstract As an antidiabetic agent, rosiglitazone (ROSI) binds and activates peroxisome proliferator-activator… Read More

Dissociation of dorsal hippocampal regional activation under the influence of stress [Front Behav Neurosci. 2011] – PubMed – NCBI

(Available for download as OA on Frontiers – just click through the link) via Dissociation of dorsal hippocampal regi… [Front Behav Neurosci. 2011] – PubMed – NCBI. Passecker J, Hok V, Della-Chiesa A, Chah E, O’Mara SM. Source Trinity College Institute of Neuroscience, Trinity College Dublin Dublin, Republic of Ireland. Abstract Stress has deleterious effects on brain, body, and behavior… Read More