What’s it worth? The economic case for medical research

Originally posted on Wellcome Trust Blog:
What’s it worth, a report published today, is one of the first ever estimates of the economic gains from investment in publicly funded UK cancer research. The research was commissioned by the Wellcome Trust, Academy of Medical Sciences, Cancer Research UK and the Department of Health. Liz Allen, Head…

A summary of the evidence that most published research is false | Simply Statistics

A ‘must-read’ piece on two major ideas wandering about the literature at the moment, namely that: Most published research is false There is a reproducibility crisis in science via A summary of the evidence that most published research is false. Related articles A summary of the evidence that most published research is false (simplystatistics.org) Biomedical… Read More

Impaired capacity for autonoetic reliving during autobiographical event recall in mild Alzheimer’s disease

Take-home message: Autonoesis or ‘Autonoetic consciousness is the human ability to mentally place ourselves in the past, in the future, or in counterfactual situations, and to analyze our own thoughts‘ (wiki). Here, we focus on impairments of autonoesis in Alzheimer’s disease (AD), using the Episodic Autobiographical Memory Interview (EAMI). We find impairments in AD patients with the following pattern: AD [Download the paper]… Read More

Maybe neuroscience needs ‘malbrain’ to complement cell biology’s ‘cancer’ in the public mind…***

Previously, I wondered why there was no hue-and-cry over the huge disinvestment in brain research over the past decade, and why, by comparison, cancer research does well.* ‘Cancer‘ is understood by the public at large, by the political establishment, by the pharmaceutical companies and a host of other stakeholders as a single-word issue of great and pressing concern to… Read More

Age and cortisol levels modulate judgment of positive and negative facial expressions.

Age and cortisol levels modulate judgment of positive and negative facial expressions. Psychoneuroendocrinology. 2012 Jun;37(6):827-35. doi: 10.1016/j.psyneuen.2011.09.015. Epub 2011 Oct 26. [Download here] Feeney J, Gaffney P, O’Mara SM. Source School of Psychology and Institute of Neuroscience, Trinity College, Dublin, Ireland. feeneyj@tcd.ie Abstract There is some evidence that older adults respond to emotional stimuli differently to young adults, and… Read More

Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457.

Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457 (available here) Callaghan CK, Hok V, Della-Chiesa A, Virley DJ, Upton N, O’Mara SM. Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland. callaghc@tcd.ie Abstract Alterations in synaptic plasticity and neurocognitive function with age have been well documented in the literature. These changes are… Read More