The subiculum: what it does, what it might do, and what neuroanatomy has yet to tell us.

Take-home message: a combined review and theory, presenting some ideas on the functions of the subiculum. I argue that there is a dorso-ventral segregation of function within the subiculum: the dorsal component appears principally concerned with the processing of information about space, movement and memory, whereas the ventral component appears to play a major regulatory role… Read More

Stability of subicular place fields across multiple light and dark transitions.

Stability of subicular place fields across multiple light and dark transitions. Take-home message: subicular place cells have larger and coarser place cells than CA1 cells; a plurality of subicular cells are stable across multiple light-dark-light transitions, however (not too dissimilar to CA1 cells).  [Download the paper.] Eur J Neurosci. 2010 Aug;32(4):648-58. doi: 10.1111/j.1460-9568.2010.07308.x. Brotons-Mas JR,… Read More

Roles for the cyclooxygenases (especially COX 2) in learning and memory, as well as in synaptic plasticity.

A pair of papers which focus on the role the inducible inflammatory regulating enzyme COX2 plays in learning and memory. These papers proceeded from earlier work of ours, showing that the bacterial endotoxin lipopolysaccharide (LPS) blocked synaptic plasticity but not synaptic transmission CA1-subiculum pathway in vivo. LPS induces the expression of COX2, amongst other things, and it seemed reasonable to… Read More

Roles for the subiculum in spatial information processing, memory, motivation and the temporal control of behaviour.

Take-home message: The subiculum is in a pivotal position governing the output of the hippocampal formation. Despite this, it is a rather under-explored and sometimes ignored structure. Here, we discuss recent data indicating that the subiculum participates in a wide range of neurocognitive functions and processes. More research required! [Download the paper] Roles for the subiculum… Read More

Hippocampal-anterior thalamic pathways for memory: uncovering a network of direct and indirect actions.

Our major theoretical take and review of the extended brain systems that support explicit, declarative memory in the brain. [Download the paper.] Take-home message: there’s a lot more to memory than the hippocampal formation, and you forget (!) the connected thalamic structures at your peril, because the anterior thalamus provides a subcortical circuit supporting memory and spatial… Read More

Interactions Between Paired-Pulse Facilitation, Low-Frequency Stimulation And Behavioral Stress In The Pathway From Hippocampal Area CA1 To The Subiculum: Dissociation Of Baseline Synaptic Transmission From Paired-Pulse Facilitation And Depression Of The Same Pathway.

Here’s an old and difficult to access paper (Download: Commins & O’Mara Psychobiol) of ours from Psychobiology – from the days before all journals were online. Hard to remember those days now… Psychobiology evolved into Cognitive, Affective, & Behavioral Neuroscience (see past titles here – scroll to bottom). (This is the longest title on any paper I have ever published…) Commins,… Read More