Decoding signal processing in thalamo-hippocampal circuitry: implications for theories of memory and spatial processing.

Our latest paper, focusing on signals afferent to the hippocampal formation as determinants of hippocampal dynamics, and therefore memory and spatial cognition [download]. Brain Res. 2014 Dec 9. pii: S0006-8993(14)01672-2. doi:10.1016/j.brainres.2014.12.003. Decoding signal processing in thalamo-hippocampal circuitry: implications for theories of memory and spatial processing. Tsanov M, O׳Mara SM Highlights Thalamo-hippocampal projections are vital for episodic… Read More

Decoding signal processing in thalamo-hippocampal circuitry: implications for theories of memory and spatial processing

Decoding signal processing in thalamo-hippocampal circuitry: implications for theories of memory and spatial processing Marian Tsanov and Shane M. O’Mara Our latest paper. Highlights • Thalamo-hippocampal projections are vital for episodic memory formation. • There is extensive connectivity between these structures. • We examine the signals processed within this circuitry. • We focus on head… Read More

Respiratory cycle entrainment of septal neurons mediates the fast coupling of sniffing rate and hippocampal theta rhythm

Our latest paper: Respiratory cycle entrainment of septal neurons mediates the fast coupling of sniffing rate and hippocampal theta rhythm Take-home message: We suggest that the respiratory system entrains septal neurons, and this entrainment in turn results in the coupling of sniffing and hippocampal theta. Pharmacological inactivation of the medial septum  decreases both theta and… Read More

Oscillatory entrainment of thalamic neurons by theta rhythm in freely moving rats.

Take-home message: The thalamus plays a key role in  learning and memory. However, the neurons of the anteroventral nucleus have not been characterised in vivo. Here, we provide a framework for the classification of neuron type, based on their electrophysiological phenotype, and show that many of these cells are theta-modulated (a strong 7-12 Hz oscillation in the EEG, studied most frequently in… Read More

Theta-modulated head direction cells in the rat anterior thalamus.

Take-home message – two key findings: (1) there are head-direction cells in the anteroventral thalamus (head direction cells fire when the head is pointed in a particular orientation); (2) a large fraction of these cells are theta-modulated (a strong 7-12 Hz oscillation in the EEG, studied most frequently in the hippocampal formation). These data are interesting because they suggests that the anterior thalamus… Read More