The irregular firing properties of thalamic head direction cells mediate turn-specific modulation of the directional tuning curve

Take-home message: Anterior thalamic head direction cells are interesting in all sorts of ways. Here, we show that head direction cells remain active during sleep (how interesting is that?!), replicate the finding that these cells fire at different rates depending on whether the head makes clockwise or counterclockwise movements, and that the origin of this difference might… Read More

Pls RT: Research Professorships: Human Brain Imaging/Cognitive Neuroscience

Research Professorship in Human Brain Imaging – Cognitive Neuroscience Trinity College Dublin (TCD), in collaboration with Science Foundation Ireland (SFI), wishes to recruit a number of high calibre Research Professors in targeted scientific areas within the Biotechnology, Information and Communication Technology (ICT) & Sustainable Energy and Energy Efficiency sectors. Funding of up to €5M will… Read More

Please RT: Position vacant, Professor in Neuroscience – Trinity College, the University of Dublin

Post Title: Professor in Neuroscience  Post Status: Permanent and Full-Time [view position] Post Title: Professor in Neuroscience  Post Status: Permanent and Full-Time Department/Faculty: Discipline of Physiology, School of Medicine Reports to: Head of Discipline Location: Trinity College Institute of Neuroscience Salary: This appointment will be made on the Associate Professor salary scale in line with… Read More

Ussher Assistant Professor in Functional Neuroimaging, Trinity College, the University of Dublin

Advert here. TRINITY COLLEGE, THE UNIVERSITY OF  DUBLIN, IRELAND Ussher Assistant Professor in Functional Neuroimaging 5 Year Contract Post Trinity College Institute of Neuroscience Department of Psychiatry, School of Medicine School of Psychology The College seeks an Ussher Assistant Professor in Functional Neuroimaging who will carry out teaching and research on brain imaging relevant to… Read More

Validation of the face-name pairs task in major depression: impaired recall but not recognition

Take-home Message: memory – and especially associative memory – is impaired in a wide variety of neuropsychiatric and neurological conditions. Face-name pair learning is a useful method to tap into deficits in associative memory; usefully, it is a task dramatically impaired by lesions of the extended hippocampal formation. Here, we show that patients with depression showed… Read More

Hippocampal Volume is Decreased in Adult-Onset Hypothyroidism.

Take-home message: We provide preliminary evidence that hypothyroidism results in structural deficits in the adult human brain. Decreases in volume in the right hippocampus were evident in patients with adult-onset overt hypothyroidism, supporting some of the findings in animal models. [Download the paper] Thyroid. 2013 Nov 8. Hippocampal Volume is Decreased in Adult-Onset Hypothyroidism. Cooke G, Mullally S, Correia N, O’Mara… Read More

Oscillatory entrainment of thalamic neurons by theta rhythm in freely moving rats.

Take-home message: The thalamus plays a key role in  learning and memory. However, the neurons of the anteroventral nucleus have not been characterised in vivo. Here, we provide a framework for the classification of neuron type, based on their electrophysiological phenotype, and show that many of these cells are theta-modulated (a strong 7-12 Hz oscillation in the EEG, studied most frequently in… Read More

Theta-modulated head direction cells in the rat anterior thalamus.

Take-home message – two key findings: (1) there are head-direction cells in the anteroventral thalamus (head direction cells fire when the head is pointed in a particular orientation); (2) a large fraction of these cells are theta-modulated (a strong 7-12 Hz oscillation in the EEG, studied most frequently in the hippocampal formation). These data are interesting because they suggests that the anterior thalamus… Read More

The psychostimulant modafinil facilitates water maze performance and augments synaptic potentiation in dentate gyrus.

The psychostimulant modafinil facilitates water maze performance and augments synaptic potentiation in dentate gyrus. [download here] Neuropharmacology. 2010 Jul-Aug;59(1-2):9-19. doi: 10.1016/j.neuropharm.2010.03.010. Epub 2010 Mar 27. Tsanov M, Lyons DG, Barlow S, González Reyes RE, O’Mara SM. Source Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland. Abstract Modafinil is a psychostimulant drug used widely for the treatment of… Read More

Hippocampal dynamics predict interindividual cognitive differences in rats.

Hippocampal dynamics predict interindividual cognitive differences in rats. Take-home message: Individual memory in old rats was assessed using DNMS. We recorded hippocampal CA1 place cells as these rats explored a familiar environment; 27% of recorded pyramidal neurons showed substantial delayed onsets of place field activity. This age-related firing onset delay occurred under basal conditions; it was… Read More