Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457.

Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457 (available here) Callaghan CK, Hok V, Della-Chiesa A, Virley DJ, Upton N, O’Mara SM. Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland. callaghc@tcd.ie Abstract Alterations in synaptic plasticity and neurocognitive function with age have been well documented in the literature. These changes are… Read More

Dissociation of dorsal hippocampal regional activation under the influence of stress [Front Behav Neurosci. 2011] – PubMed – NCBI

(Available for download as OA on Frontiers – just click through the link) via Dissociation of dorsal hippocampal regi… [Front Behav Neurosci. 2011] – PubMed – NCBI. Passecker J, Hok V, Della-Chiesa A, Chah E, O’Mara SM. Source Trinity College Institute of Neuroscience, Trinity College Dublin Dublin, Republic of Ireland. Abstract Stress has deleterious effects on brain, body, and behavior… Read More

Terrorism, Torture and Memory: Royal Irish Academy | About | Science Series

[My book ‘Why Torture Doesn’t Work: The Neuroscience of Interrogation’ (Harvard UP) can be preordered from Amazon (.com) – more details at end of post] Royal Irish Academy | About | Science Series via Royal Irish Academy | About | Science Series. This links to a podcast of an unusual interdisciplinary evening, featuring a neuroscientist (me), a political scientist (Richard… Read More

Suppressing the encoding of new information in memory: a behavioral study derived from principles of hippocampal function.

Take-home message: We show here that mixing tasks that involve executive control (the n-back task, requiring continual updating and discarding of information held presently ‘in mind’) inhibits dramatically performance on an explicit memory task (associative memory: face-name pair learning), but not performance on control recognition memory tasks. We therefore provide further behavioural evidence that memory subsystems… Read More