Roles for the subiculum in spatial information processing, memory, motivation and the temporal control of behaviour.

Take-home message: The subiculum is in a pivotal position governing the output of the hippocampal formation. Despite this, it is a rather under-explored and sometimes ignored structure. Here, we discuss recent data indicating that the subiculum participates in a wide range of neurocognitive functions and processes. More research required! [Download the paper] Roles for the subiculum… Read More

The psychostimulant modafinil facilitates water maze performance and augments synaptic potentiation in dentate gyrus.

The psychostimulant modafinil facilitates water maze performance and augments synaptic potentiation in dentate gyrus. [download here] Neuropharmacology. 2010 Jul-Aug;59(1-2):9-19. doi: 10.1016/j.neuropharm.2010.03.010. Epub 2010 Mar 27. Tsanov M, Lyons DG, Barlow S, González Reyes RE, O’Mara SM. Source Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland. Abstract Modafinil is a psychostimulant drug used widely for the treatment of… Read More

Rosiglitazone enhances learning, place cell activity, and synaptic plasticity in middle-aged rats.

Rosiglitazone enhances learning, place cell activity, and synaptic plasticity in middle-aged rats. Wang BW, Hok V, Della-Chiesa A, Callaghan C, Barlow S, Tsanov M, Bechara R, Irving E, Virley DJ, Upton N, O’Mara SM. [Download here] Neurobiol Aging. 2012 Apr;33(4):835.e13-30. doi: 10.1016/j.neurobiolaging.2011.08.013. Epub 2011 Oct 4. Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland. Abstract As an antidiabetic agent, rosiglitazone (ROSI) binds and activates peroxisome proliferator-activator… Read More